Description
This portfolio contains the entire content of each of the patents cited in this patent litigation case. You can download the portfolio as a single complete PDF file, for ease of viewing and sharing. Below is a summary/preview of what is in the PDF file.
Patents
US7126015B2 — Method for the preparation of hexahydro-furo-[2,3-b]furan-3-ol
US7595408B2 — Methods for the preparation of (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol
US8518987B2 — Pseudopolymorphic forms of a HIV protease inhibitor
Classifications
| C07D493/04 | Ortho-condensed systems |
| A61P31/00 | Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics |
| A61P31/18 | Antivirals for RNA viruses for HIV |
| A61P43/00 | Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 |
| C07D307/20 | Oxygen atoms |
| A61P31/12 | Antivirals |
Abstracts ( 3 of 3 )
The present invention relates to a method for the preparation of hexahydro-furo[2,3-b]furan-3-ol as well as novel intermediates for use in said method. More in particular the invention relates to a stereoselective method for the preparation of hexahydro-furo[2,3-b]furan-3-ol, and to a method amenable to industrial scaling up.
The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol as well as a novel intermediate, (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one for use in said methods. More in particular the invention relates to a stereoselective method for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol, as well as methods for the crystallization of (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahydro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one.
New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate and processes for producing them are disclosed.
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